Annotation Detail
Information
- Associated Genes
- SGK1
- Associated Variants
-
SGK1 OVEREXPRESSION
(
ENST00000367858.10 )
SGK1 OVEREXPRESSION ( ENST00000367858.10 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- SGK1 mRNA expression was elevated in five breast cancer cell lines which were resistant to PI3Kalpha inhibitor alpelisib (NVP-BYL719) in comparison to five sensitive cell lines. Western blots showed clear elevation of protein levels in 3/5 resistant cell lines. Ectopic SGK1 expression in sensitive MDA-MB-361 cells resulted in alpelisib resistance and preservation of phopho-S6K and phospho-4EBP with alpelisib treatment. Knockdown of SGK1 in resistant HCC1954 cells increased alpelisib sensitivity and reduced p-S6K and p-4EBP levels with alpelisib treatment. Promoter methylation at SGK1 was increased in sensitive cells compared to alpelisib resistant cell lines.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1729
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5225
- Variant URL
- https://civic.genome.wustl.edu/links/variants/693
- Rating
- 5
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Alpelisib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 27451907
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Alpelisib | Resitance or Non-Reponse | true |