Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 p.Asp835Tyr (p.D835Y)
(
ENST00000241453.12 )
FLT3 p.Asp835Tyr (p.D835Y) ( ENST00000241453.12 ) - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Event-free survival was significantly improved in patients with both NPM1 and FLT3-TKD mutations compared to patients with 1) FLT3-TKD mutations alone 2) either NPM1 or FLT3-TKD when FLT3-ITD patients were excluded from the analysis 3) neither FLT3-TKD or NPM1 mutations or FLT3-TKD alone when only de novo, normal karyotype patients were analyzed.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/171
- Gene URL
- https://civic.genome.wustl.edu/links/genes/24
- Variant URL
- https://civic.genome.wustl.edu/links/variants/56
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Better Outcome
- Pubmed
- 17965322
Drugs