Annotation Detail
Information
- Associated Genes
- MYCL
- Associated Variants
-
MYCL EXPRESSION
MYCL EXPRESSION - Associated Disease
- multiple myeloma
- Source Database
- CIViC Evidence
- Description
- Four myeloma cell lines were treated with two different BET inhibitors (I-BET151 or JQ1). Proliferation of three cell lines (KMS11, RPMI8226 and MM1S) but not U266 (only partial inhibition) was strongly inhibited by the BET inhibitors. Microarray analysis showed a downregulation of MYC-dependent genes after treatment. qRT-PCR showed that MYCL1 but not c-MYC and MYCN was expressed in U266 cells and I-BET151 induced downregulation of MYCL1. In contrast, c-MYC but not MYCL was expressed in the other cell lines and I-BET151 induced downregulation of c-MYC.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1706
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3738
- Variant URL
- https://civic.genome.wustl.edu/links/variants/670
- Rating
- 1
- Evidence Type
- Predictive
- Disease
- Multiple Myeloma
- Evidence Direction
- Supports
- Drug
- I-BET151,JQ1
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 27276402