Annotation Detail
Information
- Associated Genes
- ARAF
- Associated Variants
-
ARAF p.Ser214Cys (p.S214C)
(
ENST00000377045.9 )
ARAF p.Ser214Cys (p.S214C) ( ENST00000377045.9 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In one patient with S214C mutation, the use of sorafenib has led to more than 5 years of survival and near remission.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/17
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3
- Variant URL
- https://civic.genome.wustl.edu/links/variants/10
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Sorafenib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24569458
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sorafenib | Sensitivity | true |