Annotation Detail
Information
- Associated Genes
- HIF1A
- Associated Variants
-
HIF1A EXPRESSION
HIF1A EXPRESSION - Associated Disease
- renal cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Immunohistochemical staining was performed on 65 patients for HIF1A such that 23 were considered responders and 42 were considered non-responders. There was no difference between the two groups with regards to overall response rate to pazopanib. There was no difference between the two groups with regards to progression free survival.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1674
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2596
- Variant URL
- https://civic.genome.wustl.edu/links/variants/660
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Renal Cell Carcinoma
- Evidence Direction
- Does Not Support
- Drug
- Pazopanib
- Evidence Level
- B
- Clinical Significance
- N/A
- Pubmed
- 23881929
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Pazopanib | N/A | false |