Annotation Detail
Information
- Associated Genes
- CEBPA
- Associated Variants
-
CEBPA MUTATION
CEBPA MUTATION - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- In a group of young (<60 years old) acute myeloid leukemia (exclude acute promyelocytic leukemia) and high-risk MDS patients, those with CEBPA mutations (35/423) showed marginally improved overall survival (36% vs 31%; P = .04) than those with wildtype CEBPA.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/166
- Gene URL
- https://civic.genome.wustl.edu/links/genes/15
- Variant URL
- https://civic.genome.wustl.edu/links/variants/29
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Better Outcome
- Pubmed
- 19965647
Drugs