Annotation Detail
Information
- Associated Genes
- MET
- Associated Variants
-
MET p.Asp1246Asn (p.D1246N)
(
ENST00000318493.11,
ENST00000397752.8 )
MET p.Asp1246Asn (p.D1246N) ( ENST00000318493.11, ENST00000397752.8 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Case report of a patient with NSCLC harboring a MET exon 14 skipping mutation and initial response to crizotinib. A second biopsy at the time of progression revealed an acquired MET D1228N mutation.
- Evidence Direction
- Supports
- Disease
- Lung Non-small Cell Carcinoma
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1652
- Gene URL
- https://civic.genome.wustl.edu/links/genes/52
- Variant URL
- https://civic.genome.wustl.edu/links/variants/649
- Rating
- 2
- Evidence Type
- Predictive
- Drug
- Crizotinib
- Evidence Level
- C
- Clinical Significance
- Resistance
- Pubmed
- 27343442
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Crizotinib | Resitance or Non-Reponse | true |