Annotation Detail
Information
- Associated Genes
- ATRX
- Associated Variants
-
ATRX UNDEREXPRESSION
(
ENST00000373344.11 )
ATRX UNDEREXPRESSION ( ENST00000373344.11 ) - Associated Disease
- glioblastoma
- Source Database
- CIViC Evidence
- Description
- In a glioblastoma mouse model induced by NRAS and p53 knockdown, ATRX loss was associated with a decreased median survival (69 days vs. 84 days; P = .0032). Also, the tumors grew to a larger size at earlier time points. ATRX loss was also associated with greater microsatellite instability.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1648
- Gene URL
- https://civic.genome.wustl.edu/links/genes/525
- Variant URL
- https://civic.genome.wustl.edu/links/variants/648
- Rating
- 4
- Evidence Type
- Prognostic
- Disease
- Glioblastoma Multiforme
- Evidence Direction
- Supports
- Evidence Level
- D
- Clinical Significance
- Poor Outcome
- Pubmed
- 26936505
Drugs