Annotation Detail
Information
- Associated Genes
- FBXW7
- Associated Variants
-
FBXW7 LOSS-OF-FUNCTION
FBXW7 LOSS-OF-FUNCTION - Associated Disease
- renal cell carcinoma
- Source Database
- CIViC Evidence
- Description
- mTOR protein levels were found to underly a circadian 24-hour rhythm regulated by time-dependent Fbxw7-mediated ubiquitination. Survival rates of tumor-bearing mice with everolimus showed time-dependency consistent with mTOR protein levels. It could be hypothesized that FBXW7 loss leads to an increase in mTOR protein levels independent of circadian regulation and higher sensitivity to mTOR inhibitors.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1628
- Gene URL
- https://civic.genome.wustl.edu/links/genes/12903
- Variant URL
- https://civic.genome.wustl.edu/links/variants/637
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Renal Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Everolimus
- Evidence Level
- E
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24253377
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Everolimus | Sensitivity | true |