Annotation Detail
Information
- Associated Genes
- RAD23B
- Associated Variants
-
RAD23B EXPRESSION
RAD23B EXPRESSION - Associated Disease
- sarcoma
- Source Database
- CIViC Evidence
- Description
- Western blot analyses were performed for HR23b (RAD23B) expression sarcoma cell lines after treatment with vorinostat, belinostat, mocetinostat and entinostat. All HDACi were able to regulate proliferation and apoptosis in vitro. Sensitivity to vorinostat correlated significantly with HR23b protein expression. IHC in 523 patient samples revealed high HR23b expression in 12.5% of sarcomas (among them malignant peripheral nerve sheath tumours, pleomorphic liposarcomas, leiomyosarcomas, dedifferentiated liposarcomas, synovial sarcomas and angiosarcomas) and 23.2% of GIST.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1597
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4760
- Variant URL
- https://civic.genome.wustl.edu/links/variants/625
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Sarcoma
- Evidence Direction
- Supports
- Drug
- Vorinostat
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 27499916
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vorinostat | Sensitivity | true |