Annotation Detail
Information
- Associated Genes
- DNMT3A
- Associated Variants
-
DNMT3A MUTATION
DNMT3A MUTATION - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- DNMT3A mutations associate with adverse overall survival in acute myeloid leukemia patients if they occur in the context of mutated NPM1 and FLT3-ITD (NPM1-FLT3ITD-DNMT3A phenotype), and in the context of IDH2 codon R140 mutations.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1586
- Gene URL
- https://civic.genome.wustl.edu/links/genes/18
- Variant URL
- https://civic.genome.wustl.edu/links/variants/189
- Rating
- 4
- Evidence Type
- Prognostic
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 27276561
Drugs