Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM UNDEREXPRESSION
(
ENST00000278616.10 )
ATM UNDEREXPRESSION ( ENST00000278616.10 ) - Associated Disease
- chronic lymphocytic leukemia
- Source Database
- CIViC Evidence
- Description
- 43 B-CLL patients with LoH or reduced protein levels (<50% normal expression, radioimmunoassay, western blot) of ATM were found to have significantly shorter overall survival (35.6 vs. 97.3 months; P=0.003) when compared to 108 patients with normal expression levels.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1564
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/179
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Chronic Lymphocytic Leukemia
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 9788599
Drugs