Annotation Detail
Information
- Associated Genes
- TSC1
- Associated Variants
-
TSC1 LOSS-OF-FUNCTION
TSC1 LOSS-OF-FUNCTION - Associated Disease
- bladder carcinoma
- Source Database
- CIViC Evidence
- Description
- Tumors expressing TSC1 or TSC2 mutations show notably more sensitivity to everolimus than their wild-type counterparts.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/155
- Gene URL
- https://civic.genome.wustl.edu/links/genes/46
- Variant URL
- https://civic.genome.wustl.edu/links/variants/125
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Bladder Carcinoma
- Evidence Direction
- Supports
- Drug
- Everolimus
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22923433
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Everolimus | Sensitivity | true |