Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM MUTATION
ATM MUTATION - Associated Disease
- chronic lymphocytic leukemia
- Source Database
- CIViC Evidence
- Description
- In a study of 406 previously untreated CLL cases, a multivariate analysis indicated that aberrations (N=44; mixed pathogenic germline and somatic) in exons 2-63 of ATM were significantly associated with shorter time to first treatment (HR: 1.36; 95% CI: 1.05-1.76; P = 0.021). These mutations were not significantly associated with overall survival.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1539
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/178
- Rating
- 5
- Evidence Type
- Prognostic
- Disease
- Chronic Lymphocytic Leukemia
- Evidence Direction
- Supports
- Evidence Level
- A
- Clinical Significance
- Poor Outcome
- Pubmed
- 26837699
Drugs