Annotation Detail

Information
Associated Genes
FLT3
Associated Variants
FLT3 OVEREXPRESSION ( ENST00000241453.12 )
FLT3 OVEREXPRESSION ( ENST00000241453.12 )
Associated Disease
B-cell adult acute lymphocytic leukemia
Source Database
CIViC Evidence
Description
A 25-year-old Caucasian male presented with a second relapse of B-ALL. RNA sequencing revealed FLT3 overexpression (also confirmed by IHC). The patient was treated with 22 days of sunitinib, permitting the patient to undergo a bone marrow transplant. A bone marrow biopsy showed complete clearance by variant allele frequency and the patient remains in remission 4-years post matched-unrelated donor allograft.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1528
Gene URL
https://civic.genome.wustl.edu/links/genes/24
Variant URL
https://civic.genome.wustl.edu/links/variants/603
Rating
3
Evidence Type
Predictive
Disease
Adult B-Lymphoblastic Leukemia
Evidence Direction
Supports
Drug
Sunitinib
Evidence Level
C
Clinical Significance
Sensitivity/Response
Pubmed
27181063
Drugs
Drug NameSensitivitySupported
SunitinibSensitivitytrue