Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 DELETERIOUS MUTATION
TP53 DELETERIOUS MUTATION - Associated Disease
- chronic lymphocytic leukemia
- Source Database
- CIViC Evidence
- Description
- In a cohort of 406 patients with CLL, those patients with clonal or sub-clonal mutations in TP53 had significantly shorter overall survival (HR: 1.71; 95% CI: 1.28-2.26; P = .0001).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1507
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/222
- Rating
- 5
- Evidence Type
- Prognostic
- Disease
- Chronic Lymphocytic Leukemia
- Evidence Direction
- Supports
- Evidence Level
- A
- Clinical Significance
- Poor Outcome
- Pubmed
- 26837699
Drugs