Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN DELETION ( ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 )
Associated Disease
stomach cancer
Source Database
CIViC Evidence
Description
A patient derived mouse xenograft model was established with gastric cancer cells having PTEN loss. The xenograft was resistant to monotherapy with both the pan-Akt inhibitor AZD5363, and also to the commonly used gastric cancer chemotheraputic docetaxel. When used in combination, AZD5363 and docetaxel induced significant tumor growth inhibition in comparison to monotherapy and vehicle control.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1500
Gene URL
https://civic.genome.wustl.edu/links/genes/41
Variant URL
https://civic.genome.wustl.edu/links/variants/214
Rating
1
Evidence Type
Predictive
Disease
Stomach Cancer
Evidence Direction
Supports
Drug
Capivasertib,Docetaxel
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
24088382
Drugs
Drug NameSensitivitySupported
CapivasertibSensitivitytrue
DocetaxelSensitivitytrue