Annotation Detail
Information
- Associated Genes
- FGFR1
- Associated Variants
- FGFR1 FGFR1 FUSIONS FGFR1 FGFR1 FUSIONS
- Associated Disease
- hematologic cancer
- Source Database
- CIViC Evidence
- Description
- The 2016 World Health Organization guidelines for the classification of myeloid malignancies and acute leukemia describes a new class of disease defined by myeloid or lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1435
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1885
- Variant URL
- https://civic.genome.wustl.edu/links/variants/569
- Rating
- 5
- Evidence Type
- Diagnostic
- Disease
- Hematologic Cancer
- Evidence Direction
- Supports
- Evidence Level
- A
- Clinical Significance
- Positive
- Pubmed
- 27069254
Drugs