Annotation Detail

Information
Associated Genes
PDGFRB
Associated Variants
PDGFRB PDGFRB FUSIONS PDGFRB PDGFRB FUSIONS
Associated Disease
hematologic cancer
Source Database
CIViC Evidence
Description
The 2016 World Health Organization guidelines for the classification of myeloid malignancies and acute leukemia describes a new class of disease defined by myeloid or lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1434
Gene URL
https://civic.genome.wustl.edu/links/genes/4176
Variant URL
https://civic.genome.wustl.edu/links/variants/568
Rating
5
Evidence Type
Diagnostic
Disease
Hematologic Cancer
Evidence Direction
Supports
Evidence Level
A
Clinical Significance
Positive
Pubmed
27069254
Drugs