Annotation Detail
Information
- Associated Genes
- ALK
- Associated Variants
- ALK EML4-ALK L1196M
- Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- CH5424802 treatment resulted in significant tumor regression in xenograft models produced from Ba/F3 cells expressing EML4-ALK or EML4-ALK with the L1196M mutation.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/141
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1
- Variant URL
- https://civic.genome.wustl.edu/links/variants/7
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Alectinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21575866
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Alectinib | Sensitivity | true |