Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA AMPLIFICATION ( ENST00000263967.4 )
PIK3CA AMPLIFICATION ( ENST00000263967.4, ENST00000497599.5 )
Associated Disease
stomach carcinoma
Source Database
CIViC Evidence
Description
474 cancer cell lines from the cancer cell line encyclopedia were assessed for response to the PI3Kalpha inhibitor BYL719 (Alpelisib). PIK3CA amplification was significanly associated with BYL719 response. A gastric cancer patient derived xenograft (PDX) was transplanted into two athymic mice and one was treated with BYL719. The untreated PDX grew by over 100 percent while the BYL719 tumor was reduced by 86 percent.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1403
Gene URL
https://civic.genome.wustl.edu/links/genes/37
Variant URL
https://civic.genome.wustl.edu/links/variants/212
Rating
3
Evidence Type
Predictive
Disease
Stomach Carcinoma
Evidence Direction
Supports
Drug
Alpelisib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
24608574
Drugs
Drug NameSensitivitySupported
AlpelisibSensitivitytrue