Annotation Detail
Information
- Associated Genes
- PIK3CA
- Associated Variants
-
PIK3CA p.His1047Arg (p.H1047R)
(
ENST00000263967.4,
ENST00000643187.1 )
PIK3CA p.His1047Arg (p.H1047R) ( ENST00000263967.4, ENST00000643187.1 ) - Associated Disease
- head and neck cancer
- Source Database
- CIViC Evidence
- Description
- Lentiviral transduction of PIK3CA H1047R mutation into head and neck cancer cell line SCC25 led to increased sensitivity to PI3K/mTOR inhibition with BEZ235 compared to unmanipulated cells (IC50 values 6 nM and 31 nM).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1361
- Gene URL
- https://civic.genome.wustl.edu/links/genes/37
- Variant URL
- https://civic.genome.wustl.edu/links/variants/107
- Rating
- 1
- Evidence Type
- Predictive
- Disease
- Head And Neck Cancer
- Evidence Direction
- Supports
- Drug
- Dactolisib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25855885
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dactolisib | Sensitivity | true |