Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 p.Thr227Met (p.T227M)
(
ENST00000241453.12 )
FLT3 p.Thr227Met (p.T227M) ( ENST00000241453.12 ) - Associated Disease
- renal cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In 219 patients with mostly Renal Cell Carcinoma and some Gastrointestinal Stromal tumors given sunitinib treatment, FLT3 T227M (rs1933437) was associated with the development of leukopenia. 95% confidence interval of hazard ratio of between .17 and .77.
- Variant Origin
- Common Germline
- Variant Origin
- Common Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1317
- Gene URL
- https://civic.genome.wustl.edu/links/genes/24
- Variant URL
- https://civic.genome.wustl.edu/links/variants/540
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Renal Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Sunitinib
- Evidence Level
- B
- Clinical Significance
- Adverse Response
- Pubmed
- 19667267
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sunitinib | Adverse Response | true |