Annotation Detail
Information
- Associated Genes
- MLH1
- Associated Variants
-
MLH1 METHYLATION
MLH1 METHYLATION - Associated Disease
- stomach carcinoma
- Source Database
- CIViC Evidence
- Description
- The methylation status of MLH1 was analyzed in a study of 53 paraffin-embedded gastric cancer samples. No association was found between methylation status and clinical factors. The study showed that MLH1 methylation was associated with resistance to treatment with oxaliplatin.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1315
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3532
- Variant URL
- https://civic.genome.wustl.edu/links/variants/538
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Stomach Carcinoma
- Evidence Direction
- Supports
- Drug
- Oxaliplatin
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 24748501
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Oxaliplatin | Resitance or Non-Reponse | true |