Annotation Detail
Information
- Associated Genes
- PALB2
- Associated Variants
-
PALB2 BIALLELIC INACTIVATION
PALB2 BIALLELIC INACTIVATION - Associated Disease
- pancreatic cancer
- Source Database
- CIViC Evidence
- Description
- In a patient with gemcitabine-refractory pancreatic cancer, a tumor-derived xenograft was found to be responsive to Mitomycin C. After disease progression, the patient was started on a regimen of mitomycin C, and the patient was shown to be asymptomatic after 3 years of follow-up.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1305
- Gene URL
- https://civic.genome.wustl.edu/links/genes/15013
- Variant URL
- https://civic.genome.wustl.edu/links/variants/532
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Pancreatic Cancer
- Evidence Direction
- Supports
- Drug
- Mitomycin
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21135251
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Mitomycin | Sensitivity | true |