Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM UNDEREXPRESSION
(
ENST00000278616.10 )
ATM UNDEREXPRESSION ( ENST00000278616.10 ) - Associated Disease
- pancreatic cancer
- Source Database
- CIViC Evidence
- Description
- Absent expression of ATM, as assessed by IHC in 133 pancreatic ductal adenocarcinomas, was found to be associated with dismal prognosis (median survival, 9.6 months), whereas expression of ATM was associated with increased survival (17.7 months, P = 0.001). Furthermore loss of expression of nuclear phosphorylated Ser1981-ATM (IHC) was indicative of the worst prognosis (median survival, 10.8 vs 14.3 months [low expression] vs 31.1 months [high expression], P < 0.001).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1292
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/179
- Rating
- 2
- Evidence Type
- Prognostic
- Disease
- Pancreatic Cancer
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 25423555
Drugs