Annotation Detail
Information
- Associated Genes
- PTEN
- Associated Variants
-
PTEN MUTATION
PTEN MUTATION - Associated Disease
- endometrial carcinoma
- Source Database
- CIViC Evidence
- Description
- Tumors from 35 patients (12 with partial response or stable disease) with advanced endometrial carcinoma were assessed for PTEN mutational status, revealing 12 tumors with non-identical PTEN gene mutations. No mutations found in PTEN were effective in predicting tumor response to everolimus treatment. The clinical trial associated with this study is NCT00870337.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1232
- Gene URL
- https://civic.genome.wustl.edu/links/genes/41
- Variant URL
- https://civic.genome.wustl.edu/links/variants/510
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Endometrial Carcinoma
- Evidence Direction
- Does Not Support
- Drug
- Everolimus
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23238879
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Everolimus | Sensitivity | false |