Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN DELETION ( ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 )
Associated Disease
prostate cancer
Source Database
CIViC Evidence
Description
In a phase II trial on castration-resistant prostate cancer patients, FISH detection of PTEN deletion was associated with increased progression free survival (p=0.07) and with improved PSA response (p=0.02) in response to everolimus, an mTOR pathway inhibitor.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1231
Gene URL
https://civic.genome.wustl.edu/links/genes/41
Variant URL
https://civic.genome.wustl.edu/links/variants/213
Rating
3
Evidence Type
Predictive
Disease
Prostate Cancer
Evidence Direction
Supports
Drug
Everolimus
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
23582881
Drugs
Drug NameSensitivitySupported
EverolimusSensitivitytrue