Annotation Detail
Information
- Associated Genes
- MET
- Associated Variants
-
MET EXON 14 SKIPPING MUTATION
MET EXON 14 SKIPPING MUTATION - Associated Disease
- lung adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- A patient with MET c.3028+1G>T mutation (METex14) had partial response (tumor reduction of 61%) after 13 months capmatinib. MET gene copy number was four, MET FISH 13.8 copy number, and IHC 3+.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1186
- Gene URL
- https://civic.genome.wustl.edu/links/genes/52
- Variant URL
- https://civic.genome.wustl.edu/links/variants/324
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Capmatinib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25971938
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Capmatinib | Sensitivity | true |