Annotation Detail

Information

Associated Genes: ERBB2
Associated Variants: ERBB2 p.Leu755Ser (p.L755S) ( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
ERBB2 p.Leu755Ser (p.L755S) ( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
Associated Disease: colon cancer
Source Database: CIViC Evidence
Description: Colon cancer patient derived xenografts with HER2 mutations are sensitive to HER2 targeted drugs and the greatest tumor reduction was seen with the combination of a tyrosine kinase inhibitor with trastuzumab.
Variant Origin: somatic
Variant Origin: Somatic
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/1176
Gene URL: https://civic.genome.wustl.edu/links/genes/20
Variant URL: https://civic.genome.wustl.edu/links/variants/39
Rating: 4
Evidence Type: Predictive
Disease: Colon Cancer
Evidence Direction: Supports
Drug: Trastuzumab,Neratinib,Lapatinib
Evidence Level: D
Clinical Significance: Sensitivity/Response
Pubmed: 26243863

Drugs