Annotation Detail
Information
- Associated Genes
- MDM2
- Associated Variants
-
MDM2 c.14+309T>G
(
ENST00000393412.7,
ENST00000258148.11,
ENST00000258149.11 )
MDM2 c.14+309T>G ( ENST00000258148.11, ENST00000258149.11, ENST00000393412.7 ) - Associated Disease
- head and neck cancer
- Source Database
- CIViC Evidence
- Description
- 66 HNSCC patients treated with chemoradiation were assessed for survival after a follow-up time of 10 years. Median OS was significantly shorter in patients with MDM2 SNP309 GG or GT genotypes compared with the TT genotype (p = 0.002).
- Variant Origin
- Common Germline
- Variant Origin
- Common Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1169
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3465
- Variant URL
- https://civic.genome.wustl.edu/links/variants/495
- Rating
- 2
- Evidence Type
- Prognostic
- Disease
- Head And Neck Cancer
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 26916894
Drugs