Annotation Detail
Information
- Associated Genes
- HSPH1
- Associated Variants
-
HSPH1 NUCLEAR EXPRESSION
HSPH1 NUCLEAR EXPRESSION - Associated Disease
- gastric adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- HSP110 (HSPH1) expression was immunohistochemically assessed using a tissue microarray in 210 gastric cancer patients. The overall survival rate was significantly lower in patients with high nuclear expression (N=121, 2+ moderate/3+ strong staining) than patients with low nuclear staining (N=89, 0 no/1+ weak staining)(P = 0.0169). Multivariate regression analysis identified expression of nuclear HSP110 as an independent prognostic factor for gastric cancer outcome (P = 0.0068). This was not found for cytoplasmic expression.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1162
- Gene URL
- https://civic.genome.wustl.edu/links/genes/8614
- Variant URL
- https://civic.genome.wustl.edu/links/variants/490
- Rating
- 2
- Evidence Type
- Prognostic
- Disease
- Gastric Adenocarcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 26943774
Drugs