Annotation Detail
Information
- Associated Genes
- TBK1
- Associated Variants
-
TBK1 OVEREXPRESSION
(
ENST00000331710.10 )
TBK1 OVEREXPRESSION ( ENST00000331710.10 ) - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- Preclinical study in melanoma cell lines. TBK1 depletion (siRNA) inhibited migration and invasion, whereas its constitutive overexpression led to an increase in invasion. In MEK-resistant NRAS mutant melanoma cell lines, TBK1 depletion or inhibition (AZ909) in combination with MEK inhibitors (selumetinib) promoted apoptosis in 3D culture.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1138
- Gene URL
- https://civic.genome.wustl.edu/links/genes/11322
- Variant URL
- https://civic.genome.wustl.edu/links/variants/483
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Supports
- Drug
- AZ909,Selumetinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24962318
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AZ909 | Sensitivity | true |
| Selumetinib | Sensitivity | true |