Annotation Detail

Information
Associated Genes
DNMT3A
Associated Variants
DNMT3A R882
DNMT3A R882
Associated Disease
acute myeloid leukemia
Source Database
CIViC Evidence
Description
DNMT3A mutations (59% of which were R882) were associated with intermediate risk cytogenetics (including normal karyotype).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/113
Gene URL
https://civic.genome.wustl.edu/links/genes/18
Variant URL
https://civic.genome.wustl.edu/links/variants/32
Rating
4
Evidence Type
Diagnostic
Disease
Acute Myeloid Leukemia
Evidence Direction
Supports
Evidence Level
B
Clinical Significance
Positive
Pubmed
21067377
Drugs