Annotation Detail
Information
- Associated Genes
- DNMT3A
- Associated Variants
-
DNMT3A R882
DNMT3A R882 - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- DNMT3A mutations (59% of which were R882) were associated with an intermediate risk cytogenetic profile, normal cytogenetic profile, and M4 and M5 FAB subtypes.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/112
- Gene URL
- https://civic.genome.wustl.edu/links/genes/18
- Variant URL
- https://civic.genome.wustl.edu/links/variants/32
- Rating
- 5
- Evidence Type
- Diagnostic
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Positive
- Pubmed
- 21067377
Drugs