Annotation Detail
Information
- Associated Genes
- CIP2A
- Associated Variants
-
CIP2A UNDEREXPRESSION
(
ENST00000295746.13 )
CIP2A UNDEREXPRESSION ( ENST00000295746.13 ) - Associated Disease
- pancreatic ductal adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- Researchers studied the effect of CIP2A expression in relation to gemcitabine sensitivity via SW1990 cell lines. SW1990 cells with CIP2A expression knocked-down displayed lower IC50 (p=.024), indicating a sensitivity to gemcitabine.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1118
- Gene URL
- https://civic.genome.wustl.edu/links/genes/13948
- Variant URL
- https://civic.genome.wustl.edu/links/variants/475
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Pancreatic Ductal Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Gemcitabine
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26894380
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Gemcitabine | Sensitivity | true |