Annotation Detail
Information
- Associated Genes
- FGFR1
- Associated Variants
-
FGFR1 AMPLIFICATION
(
ENST00000425967.8 )
FGFR1 AMPLIFICATION ( ENST00000425967.8 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- FGFR1-amplified breast cancer cell lines show resistance to 4-hydroxytamoxifen, which is reversed by small interfering RNA silencing of FGFR1.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1105
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1885
- Variant URL
- https://civic.genome.wustl.edu/links/variants/267
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Afimoxifene
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 20179196
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Afimoxifene | Resitance or Non-Reponse | true |