Annotation Detail
Information
- Associated Genes
- FGFR1
- Associated Variants
- FGFR1 ZNF198-FGFR1 FGFR1 ZNF198-FGFR1
- Associated Disease
- myeloproliferative neoplasm
- Source Database
- CIViC Evidence
- Description
- A t(8;13)(p11;q12) patient with ZNF198-FGFR1-induced progressive myeloproliferative disorder was treated with PKC412. Radiographic studies performed 3 months after initiation of therapy revealed marked improvement of her cervical, mediastinal, and retroperitoneal lymphadenopathy, and marked regression of splenomegaly to normal size.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1104
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1885
- Variant URL
- https://civic.genome.wustl.edu/links/variants/466
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Chronic Myeloproliferative Disease
- Evidence Direction
- Supports
- Drug
- Midostaurin
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 15448205
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Midostaurin | Sensitivity | true |