Annotation Detail
Information
- Associated Genes
- DNMT3A
- Associated Variants
-
DNMT3A R882
DNMT3A R882 - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Daunorubicin treatment resulted in similar overall survival and disease free survival in de novo AML patients with DNMT3A R882 mutation compared to those who do not harbor this mutation.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/11
- Gene URL
- https://civic.genome.wustl.edu/links/genes/18
- Variant URL
- https://civic.genome.wustl.edu/links/variants/32
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Does Not Support
- Drug
- Daunorubicin
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 22081665
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Daunorubicin | Resitance or Non-Reponse | false |