Annotation Detail

Information
Associated Genes
ERBB2
Associated Variants
ERBB2 AMPLIFICATION ( ENST00000269571.10 )
ERBB2 AMPLIFICATION ( ENST00000269571.10 )
Associated Disease
lung small cell carcinoma
Source Database
CIViC Evidence
Description
This report details 2 case studies in relapsed HER2 positive SCLC. In the first case, a 50 pack-year patient showed intense non-mutant HER2 expression by IHC without DNA amplification, and had undergone multiple prior lines of treatment. With induction of trastuzumab and irinotecan treatment, tumor regression was observed with progression free survival of 4.5 months. Case 2 involved a 68 year old never-smoker with relapsed SCLC. Tumor showed HER2 positive SCLC cells with no amplification or mutation. Third line trastuzumab plus irinotecan brought about some symptom improvement and PFS of 3.5 months. While the efficacy of trastuzumab against NSCLC with elevated levels of wild-type HER2 expression remains unclear, the authors conclude that trastuzumab based therapy is a promising strategy for chemo-resistant SCLC.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1044
Gene URL
https://civic.genome.wustl.edu/links/genes/20
Variant URL
https://civic.genome.wustl.edu/links/variants/306
Rating
4
Evidence Type
Predictive
Disease
Lung Small Cell Carcinoma
Evidence Direction
Supports
Drug
Trastuzumab,Irinotecan
Evidence Level
C
Clinical Significance
Sensitivity/Response
Pubmed
25601188
Drugs
Drug NameSensitivitySupported
IrinotecanSensitivitytrue
TrastuzumabSensitivitytrue