Annotation Detail
Information
- Associated Genes
- EPAS1
- Associated Variants
-
EPAS1 OVEREXPRESSION
(
ENST00000263734.5 )
EPAS1 OVEREXPRESSION ( ENST00000263734.5 ) - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- Expression of EPAS1 (HIF-2alpha) was assessed in 731 colorectal cancers from two prospective cohort studies. EPAS1 overexpression was found in 322 (46%) cancers by immunohistochemistry and not significantly associated with patient survival.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1033
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1705
- Variant URL
- https://civic.genome.wustl.edu/links/variants/435
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Colorectal Cancer
- Evidence Direction
- Does Not Support
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 20363910
Drugs