Annotation Detail

Information
Associated Genes
MRE11
Associated Variants
MRE11 FRAMESHIFT MUTATION ( ENST00000323929.8 )
MRE11 FRAMESHIFT MUTATION ( ENST00000323929.8 )
Associated Disease
prostate cancer
Source Database
CIViC Evidence
Description
One patient in a cohort of 50 patients with metastatic prostate cancer had a frameshift mutation in the MRE11, ATM, MLH3 and NBN genes and showed clinical response to PARP inhibitor olaparib (16 weeks on Treatment).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1016
Gene URL
https://civic.genome.wustl.edu/links/genes/3586
Variant URL
https://civic.genome.wustl.edu/links/variants/428
Rating
2
Evidence Type
Predictive
Disease
Prostate Cancer
Evidence Direction
Supports
Drug
Olaparib
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
26510020
Drugs
Drug NameSensitivitySupported
OlaparibSensitivitytrue