Annotation Detail

Information
Associated Genes
PCSK9
Associated Variants
PCSK9 p.Cys679Ter (p.C679*) ( ENST00000302118.5, ENST00000713786.1, ENST00000710286.1, ENST00000673903.1 )
PCSK9 p.Cys679Ter (p.C679*) ( ENST00000302118.5, ENST00000673903.1, ENST00000710286.1, ENST00000713786.1 )
Associated Disease
familial hypercholesterolemia
Source Database
ClinVar
Description
NM_174936.4(PCSK9):c.2037C>A (p.Cys679Ter) AND Familial hypercholesterolemia
ClinVar Allele ID
17916
ClinVar RefSeq Alternation Syntax
NM_001407246.1:c.1662C>A
ClinVar RefSeq Alternation Syntax
NM_001407241.1:c.2079C>A
ClinVar RefSeq Alternation Syntax
NM_001407240.1:c.2160C>A
ClinVar RefSeq Alternation Syntax
NM_174936.4:c.2037C>A
ClinVar RefSeq Alternation Syntax
NM_001407243.1:c.1980C>A
ClinVar RefSeq Alternation Syntax
NM_001407244.1:c.1863C>A
ClinVar RefSeq Alternation Syntax
NM_001407247.1:c.1536C>A
ClinVar RefSeq Alternation Syntax
NM_001407245.1:c.1845C>A
ClinVar RefSeq Alternation Syntax
NM_001407242.1:c.2040C>A
Clinical Significance Description
Benign
Clinical Significance Last Update
2022-01-01
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000771132
ClinVar Disease
Familial hypercholesterolemia
Observed Origin Sample
germline
Drugs