Annotation Detail

Information
Associated Genes
PCSK9
Associated Variants
PCSK9 p.Ser127Arg (p.S127R) ( ENST00000713786.1, ENST00000710286.1, ENST00000673903.1, ENST00000302118.5 )
PCSK9 p.Ser127Arg (p.S127R) ( ENST00000302118.5, ENST00000673903.1, ENST00000710286.1, ENST00000713786.1 )
Associated Disease
Hypercholesterolemia, familial, 1
Source Database
ClinVar
Description
NM_174936.4(PCSK9):c.381T>A (p.Ser127Arg) AND Hypercholesterolemia, familial, 1
ClinVar Allele ID
17912
ClinVar RefSeq Alternation Syntax
NM_174936.4:c.381T>A
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2016-03-01
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000505185
ClinVar Disease
Hypercholesterolemia, familial, 1
Observed Origin Sample
not applicable
Observed Origin Sample
germline
Drugs