Annotation Detail

Information
Associated Genes
LRRK2
Associated Variants
LRRK2 p.Arg1441Cys (p.R1441C) ( ENST00000680790.1, ENST00000298910.12 )
LRRK2 p.Arg1441Cys (p.R1441C) ( ENST00000298910.12, ENST00000680790.1 )
Associated Disease
Autosomal dominant Parkinson disease 8
Source Database
ClinVar
Description
NM_198578.4(LRRK2):c.4321C>T (p.Arg1441Cys) AND Autosomal dominant Parkinson disease 8
ClinVar Allele ID
16977
ClinVar RefSeq Alternation Syntax
NM_198578.4:c.4321C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-10-28
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000002015
ClinVar Disease
Autosomal dominant Parkinson disease 8
Observed Origin Sample
germline
Observed Origin Sample
unknown
Pubmed
16269541
Pubmed
19667187
Pubmed
15541309
Pubmed
7898705
Drugs